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KMID : 0545120220320030302
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Journal of Microbiology and Biotechnology
2022 Volume.32 No. 3 p.302 ~ p.306
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RK-270D and E, Oxindole Derivatives from Streptomyces sp. with Anti-Angiogenic Activity
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Jang Jun-Pil
Jang Mina
Nogawa Toshihiko
Takahashi Shunji
Osada Hiroyuki
Ahn Jong-Seog
Ko Sung-Kyun
Jang Jae-Hyuk
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Abstract
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A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and High-resolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.
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KEYWORD
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Oxindole, Streptomyces sp., structural elucidation, anti-angiogenic activity
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